"Hyaluronic Acid (INCI often SODIUM HYALURONATE) itself is a substance that is widely found in human connective tissue in the skin. This complex molecule takes care of the moisture balance because of its strong hydrating properties.

Hyaluronic acid is a body’s own polymer, frequently occurring in the skin as one of the so called “glycosaminoglycans”, also called “mucopolysaccharides”, the ground substance of connective tissue. The water binding capacity of hyaluronic acid plays a key role in connective tissue, since it determines its viscosity to a high extend. The carbohydrates from which hyaluronic acid is build are alternating N-Acetylglucosamine and D-Glucuronic acid, building a non-branched polymer together. Hyaluronic acid is a polyanion because of the carboxylate functional group of D-Glucuronic acid. Hyaluronic acid is also an important part of cartilage and estimates highly its elastic properties. Furthermore, hyaluronic acid partly determines the viscosity of synovial fluid in the joints, where it has a lubricating function, enabling the joints to move smoothly.

- Molecular Weight: because hyaluronic acid is a polymer, it has a wide range of different molecular weights from 5000 to 20 Million Dalton, which results in a range of mutually varying properties. Low molecular weight is called for example 1 Million Dalton, since the molecular weight of hyaluronic acid in the human body is 4 to 5 Million Dalton on average, while the molecular weight of hyaluronic acid in synovial fluid is 3 to 4 Million Dalton.

- Signal molecules: in the human body hyaluronic acid is broken down on purpose by enzymes, called Hyaluronidases. These breakdown products are usually oligosaccharides and sometimes function as a signal molecule for fibroblasts, that produce new collagen and elastin. When hyaluronic acid is broken down even more, e.g. in the liver, the final decomposition products are a.o. water and carbon dioxide.
- Application: in cosmetics / skin care as a powerful moisturizer upon/in the skin (the horny layer) and also in cosmetic medicine as a (sub)dermal “filler”, in which case usually a cross-linked version is used. A third application in favour of the skin is cosmetic mesotherapy, where the hyaluronic acid is transferred into the skin, 1 mm down at the dermal-epidermal junction, where it stimulates the fibroblasts’ synthesis, resulting in extra collagen and elastin for the skin. "

Natural honey offers various components, which are also part of the Natural Moisturizing Factor (NMF). In that way it takes care of a good moisture balance in the skin – combined with Hyaluronic Acid in a liposome system – and does it contribute to a well-functioning skin barrier. To be used with dehydrated, sensitive and/or cellulite skin.

"Pseudoalteromonas Antarctica

A newly selected strain of arctic bacteria was found to produce very special glycoproteins, with enormous positive impact on human skin as was confirmed in a clinical study. Medex successfully uses the Pseudoalteromonas Antarctica ferment-extract in anti-wrinkle treatment, especially for dehydrated skin.

In the extreme cold conditions of arctic glaciers, these Pseudoalteromonas-bacteria were found to produce highly spreadable glycoproteins, that are able to protect the skin from dryness in extreme cold weather. Additionally, its ferment-extract was shown to exhibit wound healing properties (in-vitro), due to the strong stimulation of Collagen Type I and Type IV synthesis, as well as Elastin Synthesis. To conclude: Pseudoalteromonas Antarctica protects and regenerates your skin, when you need it most!"

Sodium Lactate is a small salt-like molecule which binds water to itself and holds it in place. These characteristics also make it a valuable ingredient to the Natural Moisturing Factor, which is responsible for the natural moisture balance in the skin.

"D-alpha-Tocopheryl Acetate (Vitamin E)
Stable form of D-alpha-Tocopherol: the natural variant of vitamin E: 100% natural and 100% active. This antioxidant protects the lipids of the cell membranes. It therefore counteracts the symptoms of skin ageing. It also has a positive effect on the moisture balance and microcirculation."